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Integrated RAS signaling defined by parallel NMR detection of ...
An NMR analysis of RAS-binding domains (effectors) placed under direct competition ... CFP alone or empty Flag vector were used as controls. More Info....

31P-NMR spectra of the Ha-ras p21.nucleotide complexes.
31P-NMR spectra of the Ha-ras p21.nucleotide complexes. ... shift virtually identical for myosin, elongation factor Tu, and the Ha-ras oncogene product p21. More Info....

NMR-based functional profiling of RASopathies and oncogenic RAS ...
We used NMR to obtain detailed mechanistic data on RAS cycling defects ... real- time bioassay, guanine nucleotide exchange factor inhibition. More Info....

Structural analysis of autoinhibition in the Ras-specific exchange ...
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1 ... NMR data demonstrate that calcium binding to the regulatory module ... More Info....

Real-time NMR Study of Three Small GTPases Reveals That ...
Guanine nucleotide exchange factor-catalyzed nucleotide exchange for both H- Ras and RhoA was inhibited by mant-substituted nucleotides, ... More Info....

Solution Structure of the State 1 Conformer of GTP-bound H-Ras ...
Recent 31P NMR studies suggested that H-Ras in the nucle- oside triphosphate ... nucleotide exchange factor for Ras. In the structure of the. More Info....

Laboratory of biomolecular NMR-spectroscopy - IBCh RAS
Laboratory of biomolecular NMR-spectroscopy: IBCh, RAS, science, journal, ... of Transmembrane Domains in Activation of Fibroblast Growth Factor Receptor 3. More Info....

NMR notes
We'll begin our discussion of TeachSpin's Pulsed NMR with the probe head ... an RF pulse, the net magnetization vector will then freely precess around B0. More Info....

HRAS - Wikipedia, the free encyclopedia
HRas is a small G protein in the Ras subfamily of the Ras superfamily of small ... is involved in regulating cell division in response to growth factor stimulation. More Info....

Conformational States of ADP Ribosylation Factor 1 Complexed with ...
Here we present 31P NMR data on ADP ribosylation factor 1 (Arf1), ... 1(T) in Ras , such as interaction with guanine nucleotide exchange factors ... More Info....

Choosing membrane mimetics for NMR structural studies of ...
(1'-rac-glycerol); LUV, large unilamellar vesicle; MAOSS, magic angle oriented sample ..... epidermal growth factor receptor (EGFR) is being studied in order to. More Info....

Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras ...
Two-dimensional proton NMR studies were performed on the c-Ha-ras ... From sequence homology with the bacterial elongation factor Tu ... More Info....

NMR structural studies of the myristoylated N-terminus of ADP ...
Small GTP binding proteins of the ADP ribosylation factor (Arf) family are ... Unlike other ras-like proteins, Arf proteins have a myristoylated amphipathic ... More Info....

Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos ...
Looking for fragments: A fragment-based screen using NMR ... GTPase K-Ras and modulate the activity of the nucleotide exchange factor Sos. More Info....

Sharon Campbell, PhD - UNC School of Medicine
Mutated Ras proteins are found in 30% of human cancers and promote ... effect on the binding of Ras to guanine nucleotide, GTP hydrolysis or exchange-factor ... We solved the NMR solution structure of the FAT domain of FAK and well as the ... More Info....

Flexibility of Ras Lipid Modifications Studied by H Solid-State NMR ...
ABSTRACT Human posttranslationally modified N-ras oncogenes are known to be implicated .... samples is restricted, and the filling factor of the radiofrequency. More Info....

Methods for Determining Structure - RCSB PDB-101
For NMR spectroscopy, it is information on the local conformation and distance ... model is supported by the experimental data found in the structure factor file. More Info....

Lyso platelet activating factor (LysoPAF) and its ... - Springer
amine gives rac-l-O-alkyl-2-acylglycero-3-phosphocholine in good overall yield. ... NMR, nuclear magnetic resonance; PAF, platelet activating factor;. More Info....

Victor Tybulewicz group - MRC National Institute for Medical ...
T cells missing Rac GTPases ... Victor Tybulewicz group ... A novel Rac- dependent checkpoint in B cell development controls entry into the splenic white pulp ... More Info....

Real-time NMR Study of Three Small GTPases Reveals That ...
nucleotide exchange factor-catalyzed nucleotide exchange for both H-Ras and RhoA .... NMR-based GTPase, GAP, and GEF Assays—H-Ras and. Rheb were ... More Info....

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